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A gene expression signature classifying telomerase and ALT immortalisation reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT

Telomere length is maintained by 2 known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The molecular mechanisms regulating the ALT phenotype are poorly understood and it is unknown how the decision of which pathway to activate is made at the cellular level. We h...

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מידע ביבליוגרפי
Main Authors: Lafferty-Whyte, Kyle, Cairney, Claire J., Will, Malcolm B., Serakinci, Nedime, Daidone, Maria-Grazia, Zaffaroni, Nadia, Bilsland, Alan, Keith, W. Nicol
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875172/
https://ncbi.nlm.nih.gov/pubmed/19684619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.238
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