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High level of telomerase RNA gene expression is associated with chromatin modification, the ALT phenotype and poor prognosis in liposarcoma

Telomere length is maintained by two known mechanisms, activation of telomerase or alternative lengthening of telomeres (ALT). The ALT pathway is more commonly activated in tumours of mesenchymal origin, although the mechanisms involved in the decision of a cell to activate either telomerase or ALT...

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מידע ביבליוגרפי
Main Authors: Cairney, C J, Hoare, S F, Daidone, M-G, Zaffaroni, N, Keith, W N
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361713/
https://ncbi.nlm.nih.gov/pubmed/18414473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604328
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