The SLO3 sperm-specific potassium channel plays a vital role in male fertility

Here we show a unique example of male infertility conferred by a gene knock-out of the sperm-specific, pH-dependent SLO3 potassium channel. In striking contrast to wild-type sperm which undergo membrane hyperpolarization during capacitation, we found that SLO3 mutant sperm undergo membrane depolariz...

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Main Authors: Santi, Celia M, Martínez-López, Pablo, de la Vega-Beltrán, José Luis, Butler, Alice, Alisio, Arturo, Darszon, Alberto, Salkoff, Lawrence
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875124/
https://ncbi.nlm.nih.gov/pubmed/20138882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.02.005
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