Pharmacologic modulation of niche accessibility via tyrosine kinase inhibition enhances marrow and thymic engraftment after hematopoietic stem cell transplantation

Essential survival signals within hematopoietic stem cell (HSC) and thymic niches are mediated by receptor tyrosine kinases, which can be reversibly inhibited using clinically available drugs. We studied whether sunitinib, a multityrosine kinase inhibitor that inhibits KIT, enhances engraftment afte...

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Detalhes bibliográficos
Main Authors: Fewkes, Natasha M., Krauss, Aviva C., Guimond, Martin, Meadors, Joanna L., Dobre, Stefania, Mackall, Crystal L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875097/
https://ncbi.nlm.nih.gov/pubmed/20231424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-248898
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