RETINOL DEHYDROGENASE 12 DETOXIFIES 4-HYDROXYNONENAL IN PHOTORECEPTOR CELLS

Mutations of the photoreceptor retinol dehydrogenase 12 (RDH12) gene cause the early-onset retinal dystrophy Leber congenital amaurosis (LCA) by mechanisms not completely resolved. Determining the physiological role of RDH12 in photoreceptors is the focus of this study. Previous studies showed that...

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Main Authors: Marchette, Lea D., Thompson, Debra A., Kravtsova, Marina, Ngansop, Thierry N., Mandal, Md Nawajes A., Kasus-Jacobi, Anne
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874966/
https://ncbi.nlm.nih.gov/pubmed/19686838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.08.005
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