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Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane-targeted alkylphospholipid analogues

BACKGROUND AND PURPOSE: Alkylphospholipid (APL) analogues constitute a new class of synthetic anti-tumour agents that act directly on cell membranes. We have previously demonstrated that hexadecylphosphocholine (HePC) alters intracellular cholesterol traffic and metabolism in HepG2 cells. We now ext...

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Detalhes bibliográficos
Main Authors: Carrasco, María P, Jiménez-López, José M, Ríos-Marco, Pablo, Segovia, Josefa L, Marco, Carmen
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874857/
https://ncbi.nlm.nih.gov/pubmed/20423345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00689.x
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