Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells

OBJECTIVE: Multiple type 1 diabetes susceptibility genes have now been identified in both humans and mice, yet mechanistic understanding of how they impact disease pathogenesis is still minimal. We have sought to dissect the cellular basis for how the highly protective mouse Idd9 region limits the e...

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Autores principales: Hamilton-Williams, Emma E., Wong, S.B. Justin, Martinez, Xavier, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S., Sherman, Linda A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Diabetes Association 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874709/
https://ncbi.nlm.nih.gov/pubmed/20299469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1801
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