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Genome-wide transcriptional analyses of islet-specific CD4+ T cells identify Idd9 genes controlling diabetogenic T cell function

Type 1 diabetes (T1D) is a polygenic disease with multiple insulin dependent diabetes loci (Idd) predisposing humans and non-obese diabetic (NOD) mice to disease. NOD.B10 Idd9 congenic mice, in which the NOD Idd9 chromosomal region is replaced by the Idd9 from T1D-resistant C57BL/10 mice, are signif...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Berry, Gregory J., Frielle, Christine, Luu, Thaiphi, Salzberg, Anna C., Rainbow, Daniel B., Wicker, Linda S., Waldner, Hanspeter
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374160/
https://ncbi.nlm.nih.gov/pubmed/25672752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401288
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