Lopinavir protein binding in HIV-1-infected pregnant women

BACKGROUND: Pregnancy may alter protein binding (PB) of highly bound protease inhibitors due to changes in plasma concentrations of albumin and α-1 acid glycoprotein (AAG). Small changes in PB can greatly impact the fraction of drug unbound (FU) exerting pharmacological effect. We report lopinavir (...

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Detalhes bibliográficos
Main Authors: Aweeka, FT, Stek, A, Best, BM, Hu, C, Holland, D, Hermes, A, Burchett, SK, Read, J, Mirochnick, M, Capparelli, EV
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874627/
https://ncbi.nlm.nih.gov/pubmed/20002783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1468-1293.2009.00767.x
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