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Identifying essential genes in bacterial metabolic networks with machine learning methods

BACKGROUND: Identifying essential genes in bacteria supports to identify potential drug targets and an understanding of minimal requirements for a synthetic cell. However, experimentally assaying the essentiality of their coding genes is resource intensive and not feasible for all bacterial organism...

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Hlavní autoři: Plaimas, Kitiporn, Eils, Roland, König, Rainer
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874528/
https://ncbi.nlm.nih.gov/pubmed/20438628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-4-56
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