Dietary Na(+) inhibits the open probability of the epithelial sodium channel in the kidney by enhancing apical P2Y(2)-receptor tone

Apical release of ATP and UTP can activate P2Y(2) receptors in the aldosterone-sensitive distal nephron (ASDN) and inhibit the open probability (P(o)) of the epithelial sodium channel (ENaC). Little is known, however, about the regulation and physiological relevance of this system. Patch-clamp studi...

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Detalhes bibliográficos
Main Authors: Pochynyuk, Oleh, Rieg, Timo, Bugaj, Vladislav, Schroth, Jana, Fridman, Alla, Boss, Gerry R., Insel, Paul A., Stockand, James D., Vallon, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874475/
https://ncbi.nlm.nih.gov/pubmed/20097874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-151506
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