Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A(1 )receptor activation

BACKGROUND: Ecto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits. Since adenosine has antinociceptive effects in rodents and humans, we hypothesized that NT5E, an enzyme that generates adenosine, migh...

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Главные авторы: Sowa, Nathaniel A, Voss, Meagen K, Zylka, Mark J
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2010
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874211/
https://ncbi.nlm.nih.gov/pubmed/20398264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-20
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