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Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A(1 )receptor activation

BACKGROUND: Ecto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits. Since adenosine has antinociceptive effects in rodents and humans, we hypothesized that NT5E, an enzyme that generates adenosine, migh...

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書誌詳細
主要な著者: Sowa, Nathaniel A, Voss, Meagen K, Zylka, Mark J
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874211/
https://ncbi.nlm.nih.gov/pubmed/20398264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-20
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