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Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A(1 )receptor activation
BACKGROUND: Ecto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits. Since adenosine has antinociceptive effects in rodents and humans, we hypothesized that NT5E, an enzyme that generates adenosine, migh...
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主要な著者: | , , |
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フォーマット: | Artigo |
言語: | Inglês |
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BioMed Central
2010
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2874211/ https://ncbi.nlm.nih.gov/pubmed/20398264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-20 |
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