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Circularization of the HIV-1 genome facilitates strand transfer during reverse transcription

Two obligatory DNA strand transfers take place during reverse transcription of a retroviral RNA genome. The first strand transfer involves a jump from the 5′ to the 3′ terminal repeat (R) region positioned at each end of the viral genome. The process depends on base pairing between the cDNA synthesi...

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Bibliographic Details
Main Authors: Beerens, Nancy, Kjems, Jørgen
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874174/
https://ncbi.nlm.nih.gov/pubmed/20430859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2039610
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