Comparative Therapeutic Effects of Velaglucerase Alfa and Imiglucerase in a Gaucher Disease Mouse Model

Gaucher disease type 1 is caused by the defective activity of the lysosomal enzyme, acid β-glucosidase (GCase). Regular infusions of purified recombinant GCase are the standard of care for reversing hematologic, hepatic, splenic, and bony manifestations. Here, similar in vitro enzymatic properties,...

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Bibliographic Details
Main Authors: Xu, You-Hai, Sun, Ying, Barnes, Sonya, Grabowski, Gregory A.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873993/
https://ncbi.nlm.nih.gov/pubmed/20505772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010750
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