Metabolic engineering for the production of shikimic acid in an evolved Escherichia coli strain lacking the phosphoenolpyruvate: carbohydrate phosphotransferase system

BACKGROUND: Shikimic acid (SA) is utilized in the synthesis of oseltamivir-phosphate, an anti-influenza drug. In this work, metabolic engineering approaches were employed to produce SA in Escherichia coli strains derived from an evolved strain (PB12) lacking the phosphoenolpyruvate:carbohydrate phos...

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Detalhes bibliográficos
Main Authors: Escalante, Adelfo, Calderón, Rocío, Valdivia, Araceli, de Anda, Ramón, Hernández, Georgina, Ramírez, Octavio T, Gosset, Guillermo, Bolívar, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873404/
https://ncbi.nlm.nih.gov/pubmed/20385022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2859-9-21
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