A mitotic kinesin-6, Pav-KLP, mediates interdependent cortical reorganization and spindle dynamics in Drosophila embryos

We investigated the role of Pav-KLP, a kinesin-6, in the coordination of spindle and cortical dynamics during mitosis in Drosophila embryos. In vitro, Pav-KLP behaves as a dimer. In vivo, it localizes to mitotic spindles and furrows. Inhibition of Pav-KLP causes defects in both spindle dynamics and...

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Bibliographic Details
Main Authors: Sommi, Patrizia, Ananthakrishnan, Revathi, Cheerambathur, Dhanya K., Kwon, Mijung, Morales-Mulia, Sandra, Brust-Mascher, Ingrid, Mogilner, Alex
Format: Artigo
Language:Inglês
Published: Company of Biologists 2010
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873223/
https://ncbi.nlm.nih.gov/pubmed/20442250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.064048
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