Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages

Forced expression of the four transcription factors Oct4, Sox2, c-Myc, and Klf4 is sufficient to confer a pluripotent state upon the murine fibroblast genome, generating induced pluripotent stem (iPS) cells. Although felt to be equivalent to embryonic stem (ES) cells, the differentiation potential o...

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Autores principales: Schenke-Layland, Katja, Rhodes, Katrin E., Angelis, Ekaterini, Butylkova, Yekaterina, Heydarkhan-Hagvall, Sepideh, Gekas, Christos, Zhang, Rui, Goldhaber, Joshua I., Mikkola, Hanna K., Plath, Kathrin, MacLellan, W. Robb
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873147/
https://ncbi.nlm.nih.gov/pubmed/18450826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2008-0033
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