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VHL Inactivation in Renal Cell Carcinoma: Implications for Diagnosis, Prognosis, and Treatment

Clear cell renal cell carcinoma (ccRCC) provides a tumor paradigm for the integration of genetics, molecular biology, therapeutic target validation, and the introduction of high impact treatment strategies. Most cases of sporadic as well as familial ccRCC acquire somatic inactivating mutations of th...

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Detalhes bibliográficos
Main Authors: Rathmell, W. Kimryn, Chen, Shufen
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2873028/
https://ncbi.nlm.nih.gov/pubmed/18095884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1586/14737140.8.1.63
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