Disruption of TrkB-Mediated Phospholipase Cγ Signaling Inhibits Limbic Epileptogenesis

The BDNF receptor, TrkB, is critical to limbic epileptogenesis, but the responsible downstream signaling pathways are unknown. We hypothesized that TrkB-dependent activation of phospholipase Cγ1 (PLCγ1) signaling is the key pathway and tested this in trkB(PLC/PLC) mice carrying a mutation (Y816F) th...

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Detaylı Bibliyografya
Asıl Yazarlar: He, Xiao Ping, Pan, Enhui, Sciarretta, Carla, Minichiello, Liliana, McNamara, James O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Society for Neuroscience 2010
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872928/
https://ncbi.nlm.nih.gov/pubmed/20445044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5821-09.2010
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