von Willebrand factor synthesized by endothelial cells from a patient with type IIB von Willebrand disease supports platelet adhesion normally but has an increased affinity for platelets.

Endothelial cells were isolated from the umbilical vein of a patient with subtype IIB von Willebrand disease, and the biosynthesis and function of von Willebrand factor (vWF) synthesized by these cells were compared with those of vWF synthesized by endothelial cells from normal individuals. The pati...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: de Groot, P G, Federici, A B, de Boer, H C, d'Alessio, P, Mannucci, P M, Sixma, J J
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287227/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2657729/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.10.3793
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