Idiotypic cascades in cancer patients treated with monoclonal antibody CO17-1A.

We have previously shown that gastrointestinal cancer patients treated with monoclonal antibody CO17-1A (Ab1) developed anti-idiotypic antibodies (Ab2) to the Ab1. We now demonstrate that patients produce anti-anti-idiotypic antibodies (Ab3) to their autologous Ab2. Ab3 were demonstrated in culture...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Wettendorff, M, Iliopoulos, D, Tempero, M, Kay, D, DeFreitas, E, Koprowski, H, Herlyn, D
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287225/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2786203/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.10.3787
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