Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptor.

Monoclonal antibodies that recognize the extracellular domain of the epidermal growth factor receptor (mAb108) were conjugated with doxorubicin through a dextran bridge. Several antibody-drug conjugates, containing different amounts of doxorubicin, retained binding capacity to human epidermoid carci...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Aboud-Pirak, E, Hurwitz, E, Bellot, F, Schlessinger, J, Sela, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2786202/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.10.3778
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