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Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptor.

Monoclonal antibodies that recognize the extracellular domain of the epidermal growth factor receptor (mAb108) were conjugated with doxorubicin through a dextran bridge. Several antibody-drug conjugates, containing different amounts of doxorubicin, retained binding capacity to human epidermoid carci...

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Bibliografiske detaljer
Main Authors: Aboud-Pirak, E, Hurwitz, E, Bellot, F, Schlessinger, J, Sela, M
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC287223/
https://ncbi.nlm.nih.gov/pubmed/2786202
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