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Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble and duplex DNA contexts

Human DNA glycosylase NEIL1 exhibits a superior ability to remove oxidized guanine lesions guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) from duplex DNA in comparison to other substrates. In the present work, Gh and Sp lesions in bubble, bulge and single-stranded DNA were found to be good s...

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Main Authors: Zhao, Xiaobei, Krishnamurthy, Nirmala, Burrows, Cynthia J., David, Sheila S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2010
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872175/
https://ncbi.nlm.nih.gov/pubmed/20099873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901852q
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