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Deregulated estrogen receptor alpha and p53 heterozygosity collaborate in the development of mammary hyperplasia

Both increased Estrogen Receptor (ER)α expression and germline disruption of one p53 allele increase breast cancer risk in women. Genetically engineered mouse models of deregulated ERα expression and p53 haploinsufficiency were used to investigate similarities and differences of each genetic lesion...

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Bibliografske podrobnosti
Main Authors: Díaz-Cruz, Edgar S., Furth, Priscilla A.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872114/
https://ncbi.nlm.nih.gov/pubmed/20466998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3450
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