Chlorambucil effectively induces deletion mutations in mouse germ cells.

The chemotherapeutic agent chlorambucil was found to be more effective than x-rays or any chemical investigated to date in inducing high yields of mouse germ-line mutations that appear to be deletions or other structural changes. Induction of mutations involving seven specific loci was studied after...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Russell, L B, Hunsicker, P R, Cacheiro, N L, Bangham, J W, Russell, W L, Shelby, M D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287208/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2726748/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.10.3704
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