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Biomolecular Surface Engineering of Pancreatic Islets with Thrombomodulin

Islet transplantation has emerged as a promising treatment for Type 1 diabetes, but its clinical impact remains limited by early islet destruction mediated by prothrombotic and innate inflammatory responses elicited upon transplantation. Thrombomodulin (TM) acts as an important regulator of thrombos...

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Bibliographic Details
Main Authors: Wilson, John T., Haller, Carolyn A., Qu, Zheng, Cui, Wanxing, Urlam, Murali K., Chaikof, Elliot L.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872068/
https://ncbi.nlm.nih.gov/pubmed/20102751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2010.01.027
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