Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III: implications for heparin efficacy.
Fibrin II monomer has a dramatic inhibitory effect on the rate of heparin-catalyzed inactivation of human alpha-thrombin by antithrombin III. At 6 microM fibrin II monomer, equivalent to the concentration of fibrinogen in plasma, the second-order rate constant was reduced by a factor of 308--from 2....
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1989
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287189/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2726739/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.10.3619 |
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