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A Paradigm Shift for the Amino Acid Editing Mechanism of Human Cytoplasmic Leucyl-tRNA Synthetase
Leucyl-tRNA synthetase (LeuRS) has been identified as a target for a novel class of boron-containing small molecules that bind to its editing active site. When the 3′ end of tRNA(Leu) binds to the editing active site, the boron crosslinks to the cis diols of its terminal ribose. The crosslinked RNA-...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2871737/ https://ncbi.nlm.nih.gov/pubmed/19702327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901111y |
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