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A Paradigm Shift for the Amino Acid Editing Mechanism of Human Cytoplasmic Leucyl-tRNA Synthetase

Leucyl-tRNA synthetase (LeuRS) has been identified as a target for a novel class of boron-containing small molecules that bind to its editing active site. When the 3′ end of tRNA(Leu) binds to the editing active site, the boron crosslinks to the cis diols of its terminal ribose. The crosslinked RNA-...

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Detalhes bibliográficos
Main Authors: Joy Pang, Yan Ling, Martinis, Susan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871737/
https://ncbi.nlm.nih.gov/pubmed/19702327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901111y
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