Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

This study describes a type of retroviral vector called double-copy (DC) vector that was designed to improve the expression of transduced genes. The unique feature of DC vectors is that the transduced gene is inserted within the U3 region of the 3' long terminal repeat (LTR). Consequently, in the in...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Hantzopoulos, P A, Sullenger, B A, Ungers, G, Gilboa, E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1989
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287169/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2542934/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.10.3519
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