Bardet-Biedl Syndrome-associated Small GTPase ARL6 (BBS3) Functions at or near the Ciliary Gate and Modulates Wnt Signaling

The expansive family of metazoan ADP-ribosylation factor and ADP-ribosylation factor-like small GTPases is known to play essential roles in modulating membrane trafficking and cytoskeletal functions. Here, we present the crystal structure of ARL6, mutations in which cause Bardet-Biedl syndrome (BBS3...

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Bibliografske podrobnosti
Main Authors: Wiens, Cheryl J., Tong, Yufeng, Esmail, Muneer A., Oh, Edwin, Gerdes, Jantje M., Wang, Jihong, Tempel, Wolfram, Rattner, Jerome B., Katsanis, Nicholas, Park, Hee-Won, Leroux, Michel R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871489/
https://ncbi.nlm.nih.gov/pubmed/20207729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070953
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