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Physical association of CD4 and the T-cell receptor can be induced by anti-T-cell receptor antibodies.

CD4 can physically associate with the CD3-T-cell receptor complex as visualized in cocapping experiments. This association occurs when the T-cell receptor is cross-linked by certain anti-variable region antibodies that appear to induce a conformational change in the receptor such that it associate w...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Rojo, J M, Saizawa, K, Janeway, C A
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1989
Subjects:
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287121/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2470100/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.9.3311
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