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Identification and characterization of a membrane-bound cytotoxin of murine cytolytic lymphocytes that is related to tumor necrosis factor/cachectin.

Cytotoxic T lymphocytes (CTLs) kill their targets by a contact-dependent mechanism. We investigated the possibility that the CTL membranes themselves could exert direct cytotoxic activity. Murine CTLs that had been fixed with paraformaldehyde retained a slow cytotoxic activity toward various target...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Liu, C C, Detmers, P A, Jiang, S B, Young, J D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC287116/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2654942/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.9.3286
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