Deep Sequencing of Human Nuclear and Cytoplasmic Small RNAs Reveals an Unexpectedly Complex Subcellular Distribution of miRNAs and tRNA 3′ Trailers

BACKGROUND: MicroRNAs (miRNAs) are ∼22-nt small non-coding regulatory RNAs that have generally been considered to regulate gene expression at the post-transcriptional level in the cytoplasm. However, recent studies have reported that some miRNAs localize to and function in the nucleus. METHODOLOGY/P...

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Bibliografiska uppgifter
Huvudupphovsmän: Liao, Jian-You, Ma, Li-Ming, Guo, Yan-Hua, Zhang, Yu-Chan, Zhou, Hui, Shao, Peng, Chen, Yue-Qin, Qu, Liang-Hu
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2010
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2871053/
https://ncbi.nlm.nih.gov/pubmed/20498841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010563
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