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Comparison of Extensive Protein Fractionation and Repetitive LC-MS/MS Analyses on Depth of Analysis for Complex Proteomes

[Image: see text] In-depth, reproducible coverage of complex proteomes is challenging because the complexity of tryptic digests subjected to LC-MS/MS analysis frequently exceeds mass spectrometer analytical capacity, which results in undersampling of data. In this study, we used cancer cell lysates...

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Main Authors: Wang, Huan, Chang-Wong, Tony, Tang, Hsin-Yao, Speicher, David W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2009
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2870931/
https://ncbi.nlm.nih.gov/pubmed/20014860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/pr900927y
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