A Novel Point Mutation in Helix 10 of the Human Glucocorticoid Receptor Causes Generalized Glucocorticoid Resistance by Disrupting the Structure of the Ligand-Binding Domain

Context: Generalized glucocorticoid resistance syndrome is a rare familial or sporadic condition characterized by partial insensitivity to glucocorticoids, caused by mutations in the glucocorticoid receptor (GR) gene. Most of the reported cases are adults, demonstrating symptoms associated with mine...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nader, Nancy, Bachrach, Bert E., Hurt, Darrell E., Gajula, Sonia, Pittman, Amy, Lescher, Rachel, Kino, Tomoshige
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2010
Materias:
Brief Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869551/
https://ncbi.nlm.nih.gov/pubmed/20335448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2009-2463
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares