Monoclonal Antibodies Specific for Disease-Associated Point-Mutants: Lamin A/C R453W and R482W

BACKGROUND: Disease-linked missense mutations can alter a protein's function with fatal consequences for the affected individual. How a single amino acid substitution in a protein affects its properties, is difficult to study in the context of the cellular proteome, because mutant proteins can...

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Bibliographic Details
Main Authors: Roblek, Marko, Schüchner, Stefan, Huber, Veronika, Ollram, Katrin, Vlcek-Vesely, Sylvia, Foisner, Roland, Wehnert, Manfed, Ogris, Egon
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869350/
https://ncbi.nlm.nih.gov/pubmed/20498701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010604
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