Characterization of Oxidative Guanine Damage and Repair in Mammalian Telomeres

8-oxo-7,8-dihydroguanine (8-oxoG) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) are among the most common oxidative DNA lesions and are substrates for 8-oxoguanine DNA glycosylase (OGG1)–initiated DNA base excision repair (BER). Mammalian telomeres consist of triple guanine repeats and are...

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Autores principales: Wang, Zhilong, Rhee, David B., Lu, Jian, Bohr, Christina T., Zhou, Fang, Vallabhaneni, Haritha, de Souza-Pinto, Nadja C., Liu, Yie
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869316/
https://ncbi.nlm.nih.gov/pubmed/20485567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000951
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