High frequency of large spontaneous deletions of DNA in tumor-derived CHEF cells.

Spontaneous mutations arising at the HPRT locus were examined in 126 mutants recovered from a series of six CHEF-derived cell lines. Altered restriction fragment patterns were characterized by Southern blot hybridization, and gene expression by RNA blot hybridization. Point mutants and gene-expressi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kaden, D A, Bardwell, L, Newmark, P, Anisowicz, A, Skopek, T R, Sager, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2928335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.7.2306
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