High frequency of large spontaneous deletions of DNA in tumor-derived CHEF cells.
Spontaneous mutations arising at the HPRT locus were examined in 126 mutants recovered from a series of six CHEF-derived cell lines. Altered restriction fragment patterns were characterized by Southern blot hybridization, and gene expression by RNA blot hybridization. Point mutants and gene-expressi...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1989
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2928335/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.7.2306 |
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