Depletion of DNMT3A Suppressed Cell Proliferation and Restored PTEN in Hepatocellular Carcinoma Cell

Promoter hypermethylation mediated by DNA methyltransferases (DNMTs) is the main reason for epigenetic inactivation of tumor suppressor genes (TSGs). Previous studies showed that DNMT1 and DNMT3B play an important role in CpG island methylation in tumorigenesis. Little is known about the role of DNM...

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Autori principali: Zhao, Zhujiang, Wu, Qingxiang, Cheng, Jian, Qiu, Xuemei, Zhang, Jianqiong, Fan, Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868982/
https://ncbi.nlm.nih.gov/pubmed/20467490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/737535
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