Depletion of DNMT3A Suppressed Cell Proliferation and Restored PTEN in Hepatocellular Carcinoma Cell

Promoter hypermethylation mediated by DNA methyltransferases (DNMTs) is the main reason for epigenetic inactivation of tumor suppressor genes (TSGs). Previous studies showed that DNMT1 and DNMT3B play an important role in CpG island methylation in tumorigenesis. Little is known about the role of DNM...

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Autors principals: Zhao, Zhujiang, Wu, Qingxiang, Cheng, Jian, Qiu, Xuemei, Zhang, Jianqiong, Fan, Hong
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868982/
https://ncbi.nlm.nih.gov/pubmed/20467490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/737535
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