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Dominant connexin26 mutants associated with human hearing loss have trans-dominant effects on connexin30

Dominant mutations in GJB2, the gene encoding the human gap junction protein connexin26 (Cx26), cause hearing loss. We investigated whether dominant Cx26 mutants interact directly with Cx30. HeLa cells stably expressing nine dominant Cx26 mutants, six associated with non-syndromic hearing loss (W44C...

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Detalhes bibliográficos
Main Authors: Yum, Sabrina W., Zhang, Junxian, Scherer, Steven S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868926/
https://ncbi.nlm.nih.gov/pubmed/20096356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2010.01.010
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