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β-Catenin stabilization imparts crypt progenitor phenotype to hyperproliferating colonic epithelia
Utilizing the Citrobacter rodentium (CR)-induced transmissible murine colonic hyperplasia (TMCH) model, we provide mechanistic basis of changes in β-catenin/APC/CKIε leading to progression and/or regression of hyperplasia in vivo. In response to CR-induced TMCH, crypt lengths increased significantly...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2868370/ https://ncbi.nlm.nih.gov/pubmed/18996369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2008.10.019 |
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