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β-Catenin stabilization imparts crypt progenitor phenotype to hyperproliferating colonic epithelia

Utilizing the Citrobacter rodentium (CR)-induced transmissible murine colonic hyperplasia (TMCH) model, we provide mechanistic basis of changes in β-catenin/APC/CKIε leading to progression and/or regression of hyperplasia in vivo. In response to CR-induced TMCH, crypt lengths increased significantly...

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Sonraí Bibleagrafaíochta
Main Authors: Sellin, Joseph H., Wang, Yu, Singh, Pomila, Umar, Shahid
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868370/
https://ncbi.nlm.nih.gov/pubmed/18996369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2008.10.019
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