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Co-localization of the amyloid precursor protein and the Notch intracellular domains in nuclear transcription factories

The β-amyloid precursor protein (APP) plays a major role in Alzheimer’s disease. The APP intracellular domain (AICD), together with Fe65 and Tip60, localizes to spherical nuclear AFT complexes that might represent sites of transcription. We now show that endogenous AICD is targeted to similar nuclea...

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Bibliografiske detaljer
Main Authors: Konietzko, Uwe, Goodger, Zoë V., Meyer, Michelle, Kohli, Bernhard M., Bosset, Jérôme, Lahiri, Debomoy K., Nitsch, Roger M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868363/
https://ncbi.nlm.nih.gov/pubmed/18403052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2008.03.001
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