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Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies
A model is investigated in which mutations that affect a complex trait (e.g., heart disease) also affect fitness because the trait is a component of fitness or because the mutations have pleiotropic effects on fitness. The model predicts that the genetic variance, and hence the heritability, in the...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2868283/ https://ncbi.nlm.nih.gov/pubmed/20133822 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906182107 |
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