Hepatitis C Virus Controls Interferon Production through PKR Activation

Hepatitis C virus is a poor inducer of interferon (IFN), although its structured viral RNA can bind the RNA helicase RIG-I, and activate the IFN-induction pathway. Low IFN induction has been attributed to HCV NS3/4A protease-mediated cleavage of the mitochondria-adapter MAVS. Here, we have investiga...

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Hauptverfasser: Arnaud, Noëlla, Dabo, Stéphanie, Maillard, Patrick, Budkowska, Agata, Kalliampakou, Katerina I., Mavromara, Penelope, Garcin, Dominique, Hugon, Jacques, Gatignol, Anne, Akazawa, Daisuke, Wakita, Takaji, Meurs, Eliane F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868028/
https://ncbi.nlm.nih.gov/pubmed/20485506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010575
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