Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

Immunotherapy for Alzheimer's disease (AD) relies on antibodies directed against toxic amyloid-beta peptide (Aβ), which circulate in the bloodstream and remove Aβ from the brain [1], [2]. In mouse models of AD, the administration of anti-Aβ antibodies directly into the brain, in comparison to t...

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Detalhes bibliográficos
Main Authors: Jordão, Jessica F., Ayala-Grosso, Carlos A., Markham, Kelly, Huang, Yuexi, Chopra, Rajiv, McLaurin, JoAnne, Hynynen, Kullervo, Aubert, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868024/
https://ncbi.nlm.nih.gov/pubmed/20485502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010549
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