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Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes

BACKGROUND: New drug targets are urgently needed for parasites of socio-economic importance. Genes that are essential for parasite survival are highly desirable targets, but information on these genes is lacking, as gene knockouts or knockdowns are difficult to perform in many species of parasites....

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Detalhes bibliográficos
Main Authors: Doyle, Maria A, Gasser, Robin B, Woodcroft, Ben J, Hall, Ross S, Ralph, Stuart A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2867826/
https://ncbi.nlm.nih.gov/pubmed/20361874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-222
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